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doi: https://doi.org/10.53941/mi.2024.100004
Yan, Z., Tran, H., Ma, D., & Xie, J. Emerging Piezoelectric Metamaterials for Biomedical Applications. Materials and Interfaces. 2024, 1(1), 13–34. doi: https://doi.org/10.53941/mi.2024.100004
Volume 1, Issue 1, Dec 2024
Copyright (c) 2024 by the authors.
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Review

Emerging Piezoelectric Metamaterials for Biomedical Applications

Zishuo Yan 1,, Huy Tran 1,, Dezun Ma 1 and Jingwei Xie 1,2,*,

1 Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA

2 Department of Mechanical and Materials Engineering, University of Nebraska Lincoln, Lincoln, NE 68588, USA

* Correspondence: jingwei.xie@unmc.edu

Received: 30 September 2024; Revised: 18 November 2024; Accepted: 20 November 2024; Published: 21 November 2024

 

Abstract: Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with the precise architecture of metamaterials. This review provides a comprehensive overview of various piezoelectric materials- such as molecular crystals, ceramics, and polymers—known for their exceptional piezoelectric performance and biocompatibility. We explore the advanced engineering approaches, including molecular design, supramolecular packing, and 3D assembly, which enable the customization of piezoelectric properties for targeted biomedical applications. Particular attention is given to the pivotal role of metamaterial structuring in the development of 0D spheres, 1D fibers and tubes, 2D films, and 3D scaffolds. Key biomedical applications, including tissue engineering, drug delivery, wound healing, and biosensing, are discussed through illustrative examples. Finally, the article addresses critical challenges and future directions, aiming to drive further innovations in piezoelectric biomaterials for next-generation healthcare technologies.

Keywords:

piezoelectric metamaterials molecular design supramolecular packing 3D assembly biomedical applications

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